Novavax vaccine exhibits 43% efficacy towards South African variant, examine finds By Reuters

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© Reuters. FILE PHOTO: Vials with a sticker studying, “COVID-19 / Coronavirus vaccine / Injection solely” and a medical syringe are seen in entrance of a displayed Novavax emblem on this illustration taken October 31, 2020. REUTERS/Dado Ruvic/Illustration

By Julie Steenhuysen

CHICAGO (Reuters) – Novavax (NASDAQ:) Inc’s COVID-19 vaccine had efficacy of 43% towards infections brought on by the South African variant in a bunch that included individuals with and with out HIV, and 51% in individuals who had been HIV destructive, in line with a brand new evaluation revealed on Wednesday.

The post-hoc evaluation was revealed within the New England Journal of Medication together with full information from the corporate’s trial in South Africa, which included almost 2,700 volunteers who had not been beforehand contaminated with the coronavirus.

Outcomes introduced in January confirmed efficacy of 49.4% towards symptomatic COVID-19 within the South African trial taking a look at a combination of the unique virus and the South African variant, and 60.1% amongst those that had been HIV-negative.

The examine additionally confirmed that prior an infection with an earlier model of the virus didn’t cut back the chance of COVID-19 brought on by the South African variant amongst individuals who received placebo photographs.

The common age of trial volunteers was 32. Most instances had been mild-to-moderate.

The examine didn’t present information on efficacy of the Novavax vaccine in stopping extreme illness or hospitalization, “probably the most necessary elements in figuring out the usefulness of a vaccine,” mentioned Dr Peter English, a retired advisor in communicable illness management and former chair of the British Medical Affiliation’s Public Well being Medication Committee.

“Most vaccines are much less efficient at stopping gentle illness than they’re at stopping extreme illness; so this vaccine might grow to be way more efficient at stopping hospital admissions and deaths – we merely don’t know, but,” mentioned English, who was not concerned within the examine.

The trial’s predominant objectives had been to check how the vaccine carried out in individuals who had been HIV destructive, in addition to those that had been HIV constructive and medically steady. The examine excluded different volunteers taking medication to suppress the immune system or these with auto-immune ailments, which might cut back vaccine efficacy. Amongst these evaluated, 94% had been HIV destructive and 6% had been HIV constructive.

Novavax has mentioned it’s making new variations of its vaccineto shield towards rising virus variants. The corporate is anticipated to report information from its ongoing late-stage examine in the USA and Mexico within the second quarter.

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