J&J scientists refute concept that COVID-19 vaccine’s design linked to clots By Reuters

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© Reuters. FILE PHOTO: A girl receives a dose of the Johnson & Johnson coronavirus illness (COVID-19) vaccine at vaccination heart in Chinatown, in Chicago

By Julie Steenhuysen

CHICAGO (Reuters) – Scientists at Johnson & Johnson (NYSE:) on Friday refuted an assertion in a serious medical journal that the design of their COVID-19 vaccine, which is analogous AstraZeneca (NASDAQ:)’s, could clarify why each have been linked to very uncommon mind blood clots in some vaccine recipients.

America earlier this week paused distribution of the J&J vaccine to analyze six instances of a uncommon mind blood clot generally known as cerebral venous sinus thrombosis (CVST), accompanied by a low blood platelet depend, in U.S. ladies underneath age 50, out of about 7 million individuals who bought the shot.

The blood clots in sufferers who obtained the J&J vaccine bear shut resemblance to 169 instances in Europe reported with the AstraZeneca vaccine, out of 34 million doses administered there.

Each vaccines are primarily based on a brand new expertise that makes use of a modified model of adenoviruses, which trigger the frequent chilly, as vectors to ferry directions to human cells.

The U.S. Meals and Drug Administration is scrutinizing this design behind each vaccines to see whether it is contributing to the danger.

In a letter on Friday within the New England Journal of Medication, J&J scientists refuted a case report revealed earlier this week by Kate Lynn-Muir and colleagues on the College of Nebraska, who asserted that the uncommon blood clots “could possibly be associated to adenoviral vector vaccines.”

In an interview with Reuters on Thursday, Dr. Anthony Fauci, the highest U.S. infectious illness professional and an adviser to the White Home, stated the truth that they’re each adenovirus vector vaccines is a “fairly apparent clue” that the instances could possibly be linked to the vector.

“Whether or not that’s the reason, I can not say for positive, nevertheless it actually is one thing that raises suspicion,” Fauci stated.

Within the correspondence on Friday, Macaya Douoguih, a scientist with J&J’s Janssen vaccines division, and colleagues identified that the vectors utilized in its vaccine and the AstraZeneca shot are “considerably totally different” and that these variations might result in “fairly totally different organic results.”

Particularly, they famous that the J&J vaccine makes use of a human adenovirus whereas the AstraZeneca vaccine makes use of a chimpanzee adenovirus. The vectors are additionally from totally different virologic households or species, and use totally different cell receptors to enter cells.

The J&J shot additionally consists of mutations to stabilize the so-called spike protein portion of the coronavirus that the vaccine makes use of to provide an immune response, whereas the AstraZeneca vaccine doesn’t.

“The vectors are very totally different,” stated Dr. Dan Barouch of the Middle for Virology and Vaccine Analysis at Harvard’s Beth Israel Deaconness Medical Middle in Boston, who helped design the J&J vaccine.

“The implications of points with one vector for the opposite one will not be clear at this level,” he stated in an interview earlier this week.

The J&J scientists stated within the letter there was not sufficient proof to say their vaccine triggered the blood clots they usually proceed to work with well being authorities to evaluate the info.

A panel of advisers to the U.S. Facilities for Illness Management and Prevention are anticipated to satisfy on April 23 to find out whether or not the pause on use of the J&J vaccine may be lifted.

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